What is Chroneme's AUROC score?

Chroneme achieved an AUROC of 0.926 in validation across 208 hospitals, outperforming the best general-purpose AI (Claude Sonnet 4.6, AUROC 0.849) on the same clinical data.

How early does Chroneme detect deterioration?

Chroneme detects clinical deterioration hours to days before standard ICU early warning systems flag anything. Median lead time is 35 hours before standard scoring systems.

How was Chroneme validated?

Chroneme was validated across hundreds of thousands of ICU stays from 208 hospitals using the eICU Collaborative Research Database (eICU-CRD v2.0) and MIMIC-IV v3.1 from PhysioNet.

Is Chroneme a black box AI?

No. Chroneme is built on deterministic clinical rules and Bayesian inference. Every alert and risk score can be traced to the underlying evidence. It is designed to be questioned, understood, and trusted by clinicians.

A New Sense for Medicine

The first clinical AI built to show its work.Chroneme reads how your health changes over time. Every signal, from every provider, across years. And when something is developing, it knows. Before the doctor. Before the diagnosis. Before the emergency. No black box, by design. Intelligence clinicians can question, understand, and trust.Validated in the hardest place in medicineWe tested Chroneme across hundreds of thousands of ICU stays from 208 hospitals. It detected deterioration hours to days before standard scoring systems flagged anything. AUROC 0.926, outperforming the best general-purpose AI (0.849) on the same clinical data.FoundersZohaib Akhtar is the CEO and founder of Chroneme. His background spans medicine, public health, biomedical design, business, and AI systems. Trained at Johns Hopkins Medicine, Bloomberg School of Public Health, Cleveland Clinic, Northwestern Kellogg, and Aarhus University. Also founder of OpenCura.Chenyu Li, Co-Founder. Adam Wolfe, Co-Founder.Founded 2025. Chroneme, Inc. 13 patent families filed. Contact: mail@chroneme.com

A New Sense for MedicineFor most of medical history, seeing a patient required being in the room. Distance and time were physical limits on what medicine could do. Sensors, continuous data, and the math for reading multi-signal trajectories at scale are now giving medicine a new sense: continuous perception of how a person's health changes across time.NASA has been building the foundations of this from the inside for decades, through bioastronautics research, ISS crew health monitoring, and now the Artemis program. SpaceX, Axiom Space, and Blue Origin are extending crew health work to commercial spaceflight. DARPA and USSOCOM are doing the parallel work for special operators and pilots.Chroneme is the layer that reads health across time. The same architecture that reads a slow drift in an ICU reads a driver's fatigue across six months on the road, an athlete's accumulating wear across a season, or an astronaut's cardiovascular signals across a mission. Validated on ICU data from more than 200 hospitals. Identifies clinical deterioration hours to days earlier than standard early warning scores.